Efektivitas Monitoring Kadar Feritin Pasca Transfusi pada Anak dengan Thalassemia: Systematic Literature Review
Keywords:
kadar feritin, monitoring, thalassemia, transfusi darahAbstract
Thalassemia merupakan kelainan darah herediter yang memerlukan transfusi darah berulang sehingga meningkatkan risiko penumpukan zat besi (iron overload) dan berbagai komplikasi organ. Monitoring kadar feritin merupakan indikator penting untuk mengevaluasi beban zat besi serta menilai efektivitas pemantauan pascatransfusi pada anak dengan thalassemia. Systematic Literature Review ini mengikuti pedoman PRISMA 2020. Pencarian literatur dilakukan melalui database Scopus, PubMed, dan Google Scholar terhadap artikel yang dipublikasikan pada periode 2019–2025 dan dari 195 artikel yang didapat sebanyak 5 artikel memenuhi kriteria inklusi dan dinilai kualitasnya menggunakan Joanna Briggs Institute (JBI) Critical Appraisal Tools. Lima artikel yang ditelaah menunjukkan adanya hubungan yang signifikan antara frekuensi transfusi darah dan peningkatan kadar feritin. Selain itu, kepatuhan terhadap terapi kelasi besi berperan penting dalam mempertahankan kadar feritin tetap terkendali. Monitoring kadar feritin secara berkala penting untuk mendeteksi iron overload secara dini serta mendukung optimalisasi terapi kelasi besi pada anak dengan thalassemia.
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